Penicillin allergy
author 1, author 2 January 01, 2025 #hypersensitivity #drugs
pearls
- ? not sure if in evidence but some staff tends to wait 6 months prior to challenge since index reaction
- if reaction was recent, ie. 4-6 weeks ago, the risk of false negative with skin testing is higher.
Toronto approach for adults
- if severe reaction history or recent (<1 year) => skin test first. If non concerning history and distant, direct to challenge.
- if reaction is delayed, wait for IDT delayed read assuming it is not a high risk reaction (ie SJS TENS)
- if negative go forward with challenge. otherwise hold off.