rough notes

definition/ddx

sx form 2 systems increased mast cell mediators ie tryptase something else

MMCAS cloncal? idk somethin g? other criteria with BMB

Physiology

Mast cells located most tissues of the body contain ++ different cytokines ... proteases, histamine, leukotrienes, etc. important gene is cKIT - can have a GOF that causes constituative activation...

Investigations:

Tryptase ? other?

from my electives this is what else was sent: (I cannot exactly explain the reasoning nor any guidelines for this yet) ANA RF APLA workup Anti TPO TG TSH anti parietal cell antibody SPEP quant ig ttg antibody for celiac

Treatment

h1 h2 mast cell stabl LTRA epi PRN venom immunotherapy cofactors mgment ige blocker